Four pathways. One capsule.

The research in children with ASD and ADHD keeps pointing at the same biology: folate that can't get into the brain, methylation that runs slow, cells short of energy, and neurotransmitters short of their cofactors. Many children eat well and take a multivitamin and still struggle with language, because standard folic acid uses the very door that antibodies can block. Speech Essentials was formulated to work on all four pathways together, with the folate form the trials used.*

What we put in, and what it supports*

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Folate delivery to the brain

Folinic acid (calcium folinate), 10 mg or 12 mg per capsule, the form used in the folinic-acid trials. Supports healthy nerve function and the folate route that stays open when the main receptor is blocked.

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Methylation

Folinic acid becomes 5-MTHF, then SAMe, with B12 as the partner. Supports normal methylation, the process behind brain-cell signalling.

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Cellular energy

Adenosylcobalamin, the mitochondrial B12, plus riboflavin-5-phosphate in Improved. Supports healthy energy and stamina.

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Neurotransmitter production

Pyridoxal-5-phosphate, the active B6 the brain uses to make serotonin, dopamine and GABA. Supports calm and focus.

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Is Speech Essentials for your child?

Consider it if:

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A speech or language delay

and you want nutritional support alongside therapy.

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Focus, attention and learning

are where you want more support.

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Low energy

or a child who tires easily.

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On the autism spectrum, or ADHD

and you want the nutrients the research in these children has focused on.

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Folic-acid multivitamins never did anything

folinic acid takes a different route.

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Your practitioner mentioned folinic acid or leucovorin

and you want a lactose-free supplement form.

A proprietary formula. Not a copy of anything.

We know of no other capsule that combines folinic acid with active B2, active B6 and two forms of B12 in one dose. The high-dose folinic powders on the market are single-ingredient with a few cofactors; children's multivitamins are broad but low-dose; prescription leucovorin is the same folate molecule as a tablet, typically made with lactose.

Speech Essentials is made with folinic acid (calcium folinate), the same folate molecule, 5-formyltetrahydrofolate, that leucovorin is based on and the compound used in the folinic-acid studies in children with ASD (Frye 2018, PMC5794882; Renard 2020). It is a dietary supplement, not a drug: not FDA-approved, not a substitute for any prescribed medication, and we make no claim of pharmaceutical equivalence. Same folate, made without lactose, in a capsule you can open and titrate.

Speech Essentials Improved bottle with capsules and a smiling child

What the trials found

Frye 2018, Molecular Psychiatry (PMC5794882). 48 children with ASD and language impairment, 12 weeks, folinic acid versus placebo: verbal-communication scores rose about 5.7 standardized points more on folinic acid, and about 7.3 in the antibody-positive subgroup, where 65% responded versus 24% on placebo.

Rossignol & Frye 2021, J Pers Med (PMC8622150). A systematic review and meta-analysis of the folinic-acid literature: meaningful gains on social-responsiveness and behaviour scales, strongest in antibody-positive children, with a favourable safety profile.

Ramaekers 2008, Dev Med Child Neurol. A milk-free diet lowered folate-receptor-blocking antibody titers in children with cerebral folate deficiency; cow's milk raised them again. It is why Speech Essentials is made without lactose.

We report what the studies found; we don't promise it for your child. Read them yourself, then talk to your clinician.

Read the research

Lactose-free where the drug usually isn't

Prescription leucovorin is typically made as tablets with lactose as a filler. For a child whose folate-receptor antibodies react to milk proteins, that's the wrong excipient. Speech Essentials contains no lactose, gluten, soy or GMO ingredients, no synthetic folic acid, and comes in a vegetable capsule you can open and split for weight-based titration with your practitioner.

Made for ASDHelp in a GMP-compliant facility in the United States. ASDHelp, PO Box 63097, Irvine, CA 92620 · 971-999-1155 · info@asdhelps.com

See Speech Essentials Improved

Shaping tomorrow's voices today.

Speech Essentials by ASDHelp Supplements

Shaping tomorrow's voices today.

Speech Essentials by ASDHelp Supplements

Shaping tomorrow's voices today.

Speech Essentials by ASDHelp Supplements

Shaping tomorrow's voices today.

Speech Essentials by ASDHelp Supplements

Shaping tomorrow's voices today.

Speech Essentials by ASDHelp Supplements

Shaping tomorrow's voices today.

Speech Essentials by ASDHelp Supplements

Shaping tomorrow's voices today.

Speech Essentials by ASDHelp Supplements

Shaping tomorrow's voices today.

Speech Essentials by ASDHelp Supplements

Shaping tomorrow's voices today.

Speech Essentials by ASDHelp Supplements

Shaping tomorrow's voices today.

Speech Essentials by ASDHelp Supplements

Shaping tomorrow's voices today.

Speech Essentials by ASDHelp Supplements

Shaping tomorrow's voices today.

Speech Essentials by ASDHelp Supplements

Shaping tomorrow's voices today.

Speech Essentials by ASDHelp Supplements

Shaping tomorrow's voices today.

Speech Essentials by ASDHelp Supplements

Shaping tomorrow's voices today.

Speech Essentials by ASDHelp Supplements

Shaping tomorrow's voices today.

Speech Essentials by ASDHelp Supplements

  • Improved Confidence in Speech

    "I’ve been using Speech Essentials with my 7-year-old for a few months now, and I’m already seeing improvements in her speech clarity. She’s more confident and her pronunciation has really improved. We’re excited to see how things progress!"

    Olivia K.

  • Better Focus and Instruction Following

    "My son has struggled with language development and has been receiving speech therapy for a while. Since we started using Speech Essentials, I’ve noticed he’s more focused and better at following instructions. "

    Jessica R.

  • Enhanced Social Engagement

    "I can't believe the difference Speech Essentials has made for my daughter. She’s been able to express herself better, and she’s even started engaging more in social situations. It’s like a weight has been lifted off her shoulders."

    Samantha P.

    Frequently asked questions

    A daily dietary supplement combining folinic acid (calcium folinate) with activated forms of B12, B6 and B2. It supports normal methylation, nervous-system function, focus and energy.* It is not a drug and is not intended to diagnose, treat, cure or prevent any disease.

    It contains the same folate molecule, folinic acid, also called calcium folinate or 5-formyltetrahydrofolate, that prescription leucovorin is based on; the American Academy of Pediatrics lists them as one compound. Speech Essentials is a dietary supplement, not a drug, not FDA-approved, and not a substitute for any prescribed medication.

    Improved is the broader starting formula (adds riboflavin and a dual B12); Pro is higher-folinic and simpler, for precise titration or antibody-positive children. Start with Improved if unsure. See the full comparison on our Which one? page.

    The label suggested use is 1 capsule daily or as directed by your healthcare professional. Weight-based protocols exist in the research literature, but dosing for a child should be set by your physician or a qualified practitioner.

    Tell your child's doctor about every medication and supplement before starting. Do not stop or change any prescribed medication on your own.